Thalidomide Embryopathy and Limb Defects: Experiences in Habilitation of Children with Ectromelias
نویسندگان
چکیده
منابع مشابه
Thalidomide Embryopathy and Limb Defects; Esperiences in Habilitation of Children with Ectromelias.
Abnormalities oflimbs have been seen occasionally at all times. Thalidomide-embryopathy, however, has produced special types of defects of the extremities, which in variety and above all in numbers has made necessary the provision of special centres for treatment. At the Dept. of Paediatric Surgery and Orthopaedics of the University Children's Hospital, Munich, we observed from January 1959 to ...
متن کاملOffspring of male and female parents with thalidomide embryopathy: birth defects and functional anomalies.
BACKGROUND The aim of the study was to evaluate congenital malformations and functional anomalies in the offspring of Swedish parents with thalidomide embryopathy (TE). METHODS Sixty-four children (29 girls, 35 boys) with ages ranging from 0-18 years, born to 34 Swedish parents (14 women, 20 men) with TE, were studied. Data on malformations and dysfunction were collected from medical records ...
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Thalidomide remains one of the world’s most notorious drugs due to the severe birth defects it induced in children between 1957 and 1962. Yet, to some this drug is a lifesaver, as it now enjoys renaissance in the treatment for a wide range of conditions including leprosy, multiple myeloma, Behcet’s disease, and some cancers. However, thalidomide has also been linked to causing a new generation ...
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The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive survei...
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Thalidomide is the best known human teratogen. Although withdrawn from the market in 1961, thalidomide was remarketed after 1965 in several countries, for the treatment of erythema nodosum leprosum. Thalidomide has a potent immunomodulatory property and has now a number of approved and off-label uses in dermatologic, oncologic, infectious and gastrointestinal conditions. In the U.S., FDA approv...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1965
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.40.210.154